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SMN protein increase in different tissues following administration of RG7800. SMN protein increase from baseline (reported as ratio of SMN protein levels in treated vs control) in different tissues in adult C/Callele SMA mice following repeat (10 days) doses of 10 mg/kg/day PO of RG7800 (Study 12, n = 5). Bars represent mean with standard deviation. PO, per os; SMA, spinal muscular atrophy; SMN, survival motor neuron
