Figure 1. Yes-associated protein (YAP) was activated in the matrix remodeling of dilated cardiomyopathy (DCM). A, Picrosirius red staining indicated an increased collagen distribution in the DCM group. B, Quantitative assessment demonstrated the collagen volume fraction (CVF) significantly increased in the DCM group. C, Immunofluorescence staining of α-smooth muscle actin (α-SMA) confirmed the transdifferentiation of cardiac myofibroblasts in the pathogenesis of DCM. D and E, The protein levels of YAP and pYAP were significantly increased in the matrix remodeling of DCM. Data are reported as means±SD (n=8). *P<0.05, **P<0.01 vs control (t-test). In D, each lane shows protein from a different mouse. Scale bar: 100 μm.