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The ER acetylation machinery. Acetyl-CoA is synthesized in the cytosol through a multi-step process and is then transported into the ER lumen by the ER membrane transporter AT-1. In the ER lumen, acetyl-CoA is used by two ER-based acetyltransferases, ATase1 and ATase2, to acetylate ER-cargo and -resident proteins. Both ATase1 and ATase2 are type-II membrane proteins with the catalytic domain facing the lumen of the organelle.
