Table 3.
Physiochemical parameters, solubility, and plasma protein binding of top KGW compounds.
| Identifier | cPPBa (% Bound) | PSAb (A2) | gLogD (pH 7.4) | Sol6.5c(ug/mL) |
|---|---|---|---|---|
| KG81 | >99.5 | 71.4 | 3.9 | 3.1–6.3 |
| KGW44 | 84.3 | 101.7 | 4.9 | <1.6 |
| KGW59 | ND | 127.7 | >5.3 | <1.6 |
(ND: No chromatographic peak under cPPB conditions) (Sanford et al., 20181).
a
Plasma protein binding was estimated using a chromatographic method.
b
PSA values were calculated through the ChemAxon chemistry cartridge with JChem from Excel.
c
Kinetic solubility was determined by nephelometry after 30 min at room temperature.