Table 1.

Some clinical features of hereditary syndromes of primary hyperplasia with hormone excess (See also Table 2).

Syndrome	Normal serum stimulus of mutant sensor	Hormone over-secreted	Typical early age of onset of hormone excess	Selected comments about expressions
NSHPT#	Low Ca++	PTH	In fetus	Severe defects at birth reflect onset by fetal over-secretion of PTH
CNT	TSH	T4, T3	In fetus	Severe defects at birth reflect onset by fetal over-secretion of iodo-thyronines
FMPP	LH	Testosterone	1-3 yr	Not expressed in female carriers of the mutation
OHSS	CG	Estrogens, progestins, cytokines	Pregnant female	CG from the normal placenta stimulates the mutant FSH receptors in the corpus luteum of pregnancy
HAIIIA	K+	Aldosterone	1 yr	Hyperplasia is in the adrenal fasciculata with atrophy in the adrenal glomerulosa

^#Abbreviations: Congenital neonatal thyrotoxicosis CNT; Neonatal severe primary hyperparathyroidism NSHPT; hyperaldosteronism type III HAIII; Familial male-limited precocious puberty FMPP; Ovarian hyperstimulation syndrome OHSS