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. Author manuscript; available in PMC: 2019 Nov 21.
Published in final edited form as: Neuron. 2018 Oct 11;100(4):926–939.e3. doi: 10.1016/j.neuron.2018.09.029

Figure 1: Archaerhodopsin Inhibition of SOM Interneurons Decreases Interneuron Firing and Increases Pyramidal Cell Firing.

Figure 1:

A.) Schematic for T-maze delayed-non-match-to-sample test. Neural recordings are obtained during this spatial working memory task. B.) Proportions of cells with a significant increase or decrease in firing rate in response to sample phase green light as determined by bootstrapping (p<0.01) in SOM-YFP (N =394 cells) and SOM-Arch (N = 382 cells) animals. C.) Time triggered average (green light turns on at time = 0, marked by first vertical green line; green light turns off at second vertical green line) and raster plot of a cell inhibited by Archaerhodopsin during sample, delay, and choice phases. D.) Time triggered average and raster plot of a cell that is disinhibited during SOM interneuron inhibition in sample, delay, and choice phases.