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VEGF165 binding affinities to immobilized VEGFRs and NRP-1.
|
KD ± SE (nM) |
Rmax ± SE (RU) |
Red. X2 |
Adj. R2 |
|
|---|---|---|---|---|
| VEGFR-1 Fc Chimera | 3.7 ± 0.3 | 120 ± 2 | 4.2 | 0.98 |
| VEGFR-2 Fc Chimera | 18 ± 2 | 41 ± 1 | 281 | 0.99 |
| NRP-1 Fc Chimera | 22 ± 7 | 18 ± 2 | 3.21 | 0.93 |
| NRP-1 monomer | 28 ± 4 | 28 ± 2 | 2.09 | 0.99 |
Equilibrium curve fit results (red lines in Figures 4B, D, 5B and D) for the indicated receptors binding to VEGF165 (Equation 4).
