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. 2018 Nov 15;7(11):bio031534. doi: 10.1242/bio.031534

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Metabolome analysis and serial analysis of gene expression (SAGE). (A) PCA of normalized metabolic data derived from liver samples of medaka fed an HFD for 2 months (n=4) and control group (n=4). Percentage values indicated on the axes represent the contribution rate of the first (PC1) and second (PC2) principal components to the total amount of variation. (B) Heat map of the hierarchical cluster analysis. The columns indicate the HFD and the control groups. The rows indicate the normalized levels of each metabolite. The dendrogram for each heat map shows the relation of the normalized metabolite level patterns.