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. 2018 Nov 22;9:2697. doi: 10.3389/fimmu.2018.02697

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Copyright © 2018 Jensen, Potts, Ready and Patterson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PROTAC compounds induce the presentation of MHC-I peptides. (A) PROTAC compounds consist of a protein ligand (triangle) and an E3 ubiquitin-ligase recruiting factor (star). PROTAC compounds induce the proteolytic degradation of target cellular proteins through a ubiquitin-mediated (pink circle) pathway. This could result in the presentation of MHC-I peptides derived from target protein. (B) PROTAC compounds used in this study: all three target the BET family of proteins through the small molecule JQ1 while recruiting different E3 ubiquitin-ligases.