Protopopoff 2018.

Methods	Cluster‐randomized controlled village trial
Participants	3966 children analysed (21 months after intervention) aged 6 months‐14 years (excluding the severely ill), Anopheles species (pooled). Total core cluster population area ranged from 14,845 to 16,358.
Interventions	Control: LLIN, Olyset Net Intervention: LLIN, Olyset Plus
Outcomes	Malaria infection prevalence, sporozoite rate, mosquito density
Mosquito resistance status	Resistance ‐ high (17.8% mortality, N = 107)
Net treatment	Nets unholed and unwashed
Location(s)	Muleba District, Tanzania
Notes	Trial conducted: March 2014‐December 2016
Risk of bias
Bias	Authors' judgement	Support for judgement
Recruitment bias	Low risk	No participants recruited after clusters had been randomized
Were the mosquitoes in LLIN and LLIN + PBO groups comparable	Unclear risk	Resistance level was only available for the whole district, not at village level.
Collectors blinded	Low risk	Field workers were masked to net treatment.
Household blinded	Low risk	Inhabitants were masked to net treatment
Treatment allocation (was the treatment allocation sequence randomly/adequately generated	Low risk	Restricted randomization was used to allocate clusters to the study groups.
Allocation concealment (selection bias)	Low risk	Restricted randomization was used to allocate treatments to clusters
Were incomplete outcome data adequately addressed	Low risk	No incomplete outcome data
Were the raw data reported for LLIN and LLIN + PBO groups	Low risk	No missing outcome data
Clusters lost to follow‐up	Low risk	No clusters lost to follow‐up
Selective reporting (reporting bias)	Low risk	All measured outcomes appear to be reported
Correct statistical methods; adjusted for clustering	Low risk	Clustering was taken into account and adjusted for during statistical analysis
Trial authors' conflicting interest	Low risk	The trial authors declared no conflicting interests.