Table 1.
Hemodynamic variables during afterload changes
| Phenylephrine | Sodium nitroprusside | |||
|---|---|---|---|---|
| Variables | Before | After | Before | After |
| CO, L⋅min− 1 | 7.73 ± 1.40 | 7.07 ± 1.04* | 8.09 ± 1.61 | 9.89 ± 1.49* |
| SV, ml | 105 ± 11 | 96 ± 12‡ | 103 ± 11 | 119 ± 15† |
| HR, beats⋅min− 1 | 73 ± 11 | 73 ± 8 | 79 ± 11 | 75 ± 11* |
| MAP, mmHg | 80 ± 9 | 111 ± 13‡ | 81 ± 8 | 55 ± 4‡ |
| EDV, ml | 218 ± 47 | 214 ± 45 | 211 ± 43 | 212 ± 45 |
| ESV ml | 110 ± 42 | 115 ± 41 | 105 ± 40 | 89 ± 43† |
| LV Ped, mmHg | 13 ± 4 | 18 ± 4‡ | 12 ± 3 | 7 ± 3‡ |
| LV Pes, mmHg | 84 ± 11 | 122 ± 15‡ | 90 ± 12 | 60 ± 7‡ |
| Ea, mmHg⋅ml− 1 | 0.69 ± 0.13 | 1.09 ± 0.20‡ | 0.77 ± 0.16 | 0.45 ± 0.09‡ |
| Ees, mmHg⋅ml− 1 | 0.36 ± 0.12 | 0.48 ± 0.11‡ | 0.41 ± 0.14 | 0.35 ± 0.14 ‡ |
| LV ejection fraction, % | 52 ± 10 | 48 ± 9* | 52 ± 10 | 60 ± 13† |
| SVV, % | 10.9 ± 3.6 | 5.8 ± 2.3‡ | 10.9 ± 2.5 | 21.1 ± 5.9† |
| LV dP/dtmax, mmHg⋅s− 1 | 1003 ± 158 | 1245 ± 175‡ | 1089 ± 157 | 963 ± 182* |
| Femoral dP/dmax, mmHg⋅s− 1 | 306 ± 52 | 378 ± 53† | 335 ± 75 | 226 ± 52† |
| Radial dP/dtmax, mmHg⋅s− 1 | 480 ± 110 | 409 ± 69* | 463 ± 125 | 321 ± 96‡ |
Data are presented as mean ± SD
LV left ventricle, CO cardiac output, SV stroke volume, HR heart rate, MAP mean arterial pressure, EDV left ventricular end-diastolic volume, ESV left ventricular end-systolic volume, LV Ped left ventricular end-diastolic pressure, LV Pes left ventricular end-systolic pressure, Ees end-systolic elastance, Ea effective arterial elastance, SVV stroke volume variation, dP/dtmax peak rate of pressure
*P < 0.05, †P ≤ 0.001, ‡P ≤ 0.0001 vs “before” stage