Table 3.
Hemodynamic variables during contractility changes
| Esmolol | Dobutamine | |||
|---|---|---|---|---|
| Variables | Before | After | Before | After |
| CO, L⋅min−1 | 8.87 ± 1.88 | 5.15 ± 1.09‡ | 8.16 ± 2.01 | 11.23 ± 3.25‡ |
| SV, ml | 116 ± 13 | 75 ± 11‡ | 111 ± 17 | 131 ± 22‡ |
| HR, beats⋅min− 1 | 76 ± 10 | 69 ± 9† | 73 ± 10 | 85 ± 15† |
| MAP, mmHg | 73 ± 13 | 50 ± 4‡ | 71 ± 8 | 83 ± 10‡ |
| EDV, ml | 209 ± 33 | 200 ± 27 | 210 ± 28 | 208 ± 29 |
| ESV ml | 93 ± 28 | 125 ± 22† | 97 ± 23 | 74 ± 28‡ |
| LV Ped, mmHg | 15 ± 4 | 13 ± 3* | 14 ± 4 | 15 ± 4 |
| LV Pes, mmHg | 76 ± 15 | 53 ± 8† | 73 ± 11 | 85 ± 12‡ |
| Ea, mmHg⋅ml−1 | 0.53 ± 0.13 | 0.55 ± 0.12 | 0.54 ± 0.13 | 0.55 ± 0.15 |
| Ees, mmHg⋅ml− 1 | 0.37 ± 0.10 | 0.23 ± 0.06‡ | 0.33 ± 0.07 | 0.50 ± 0.11‡ |
| LV ejection fraction, % | 56 ± 7 | 38 ± 5‡ | 38 ± 5 | 53 ± 7‡ |
| SVV, % | 9.4 ± 4.4 | 17.1 ± 3.6 | 10.1 ± 3.8 | 8.9 ± 4.2* |
| LV dP/dtmax, mmHg⋅s− 1 | 1067 ± 220 | 485 ± 58‡ | 927 ± 174 | 1701 ± 384‡ |
| Femoral dP/dmax, mmHg⋅s− 1 | 292 ± 57 | 171 ± 44‡ | 287 ± 56 | 392 ± 70‡ |
| Radial dP/dtmax, mmHg⋅s− 1 | 401 ± 142 | 204 ± 66‡ | 391 ± 151 | 565 ± 192‡ |
Data are presented as mean ± SD
LV left ventricle, CO cardiac output, SV stroke volume, HR heart rate, MAP mean arterial pressure, EDV left ventricular end-diastolic volume, ESV left ventricular end-systolic volume, LV Ped left ventricular end-diastolic pressure, LV Pes left ventricular end-systolic pressure, Ees end-systolic elastance, Ea effective arterial elastance, SVV stroke volume variation, dP/dtmax peak rate of pressure
*P < 0.05, †P ≤ 0.001, ‡P ≤ 0.0001 vs “before” stage