Table 1.
Genes with highly variable copy numbers between Sri Lankan L. donovani CL-SL and VL-SL isolates
| Chr | GeneID | VL/CL Ratio | MWU-test p-value | Benjamini-Hochberg p-value | Product Description |
|---|---|---|---|---|---|
| 27 | LdBPK_271940 | 7.96 | 0.2717 | 0.3702 | D-Lactate Dehydrogenase-Like Protein |
| 27 | LdBPK_271950 | 6.84 | 0.0012 | 0.0029 | Branched-Chain Amino Acid Aminotransferase, Putative (Fragment) |
| 10 | LdBPK_100520 | 4.698 | 0.0000 | 0.0000 | Gp63, Leishmanolysin |
| 29 | LdBPK_291600 | 4.41 | 0.0000 | 0.0000 | Nodulin-Like, Putative |
| 23 | LdBPK_230360 | 4.22 | 0.0000 | 0.0000 | Hypothetical Protein, Conserved |
| 23 | LdBPK_230350 | 3.86 | 0.0022 | 0.0050 | Hypothetical Protein, Conserved |
| 23 | LdBPK_230330 | 3.85 | 0.0133 | 0.0264 | Checkpoint Protein Hus1, Putative |
| 25 | LdBPK_210020 | 3.80 | 0.0009 | 0.0023 | Histone H4 |
| 10 | LdBPK_100920 | 3.55 | 0.8462 | 0.8817 | Histone H3 |
| 23 | LdBPK_230340 | 3.47 | 0.0001 | 0.0004 | Tryptophanyl-Trna Synthetase, Putative |
| 23 | LdBPK_230320 | 3.06 | 0.2234 | 0.3163 | Zinc Finger, C3Hc4 Type (Ring Finger), Putative |
| 23 | LdBPK_230310 | 3.02 | 0.7210 | 0.7877 | Pteridine Reductase 1 |
| 11 | LdBPK_110640 | 2.95 | 0.0922 | 0.1456 | Metallo-Peptidase, Clan Mf, Family M17 (Fragment) |
| 29 | LdBPK_291590 | 2.90 | 0.3598 | 0.4576 | Asparagine Synthase, Putative |
| 10 | LdBPK_100510 | 2.55 | 0.2285 | 0.3201 | Gp63, Leishmanolysin (Fragment) |
| 23 | LdBPK_230290* | 2.49 | 0.8027 | 0.8474 | Abc-Thiol Transporter (Fragment) |
| 23 | LdBPK_230300 | 2.47 | 0.8735 | 0.9026 | Argininosuccinate Synthase, Putative |
| 23 | LdBPK_230250* | 2.47 | 0.0540 | 0.0905 | Hypothetical Protein, Conserved |
| 35 | LdBPK_353690 | 2.38 | 0.0001 | 0.0003 | Hypothetical Protein, Conserved |
| 22 | LdBPK_221370 | 2.36 | 0.0350 | 0.0616 | 40S Ribosomal Protein L14, Putative |
| 31 | LdBPK_310470 | 2.28 | 0.6628 | 0.7405 | Hypothetical Protein |
| 23 | LdBPK_230370 | 2.27 | 0.0000 | 0.0000 | Hypothetical Protein, Conserved |
| 23 | LdBPK_230260* | 2.22 | 0.1946 | 0.2790 | Hypothetical Protein, Conserved |
| 25 | LdBPK_020010 | 2.20 | 0.1855 | 0.2691 | Aminopeptidase P1, Putative |
| 15 | LdBPK_150430 | 2.19 | 0.9484 | 0.9561 | 60S Acidic Ribosomal Protein, Putative |
| 27 | LdBPK_271490 | 2.13 | 0.1280 | 0.1947 | Hypothetical Protein, Conserved |
| 11 | LdBPK_111070 | 2.13 | 0.3303 | 0.4289 | Hypothetical Protein |
| 28 | LdBPK_282050 | 2.12 | 0.4786 | 0.5652 | Zinc Transporter 3, Putative |
| 34 | LdBPK_341720 | 2.10 | 0.9113 | 0.9300 | Amastin-Like Surface Protein, Putative (Fragment) |
Benjamini-Hochberg critical value for a false discovery rate < 0.05 was considered significant and marked in bold
*Genes previously reported with high copy number variations between a cutaneous and a visceral isolate from Sri Lanka [14]