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. 2019 Jan;14(1):100–106. doi: 10.4103/1673-5374.243715

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Copyright: © Neural Regeneration Research

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CGRP immunoreactivity in different brain regions of the rhesus monkey model of recurrent migraine (immunohistochemical staining).

Cells containing CGRP showed brownish-yellow granules under the microscope after staining. CGRP-positive cells were stained brown primarily in the cytoplasm. Repeated IS stimulation of the dura in rhesus monkeys increased the immunoreactivity of CGPR in the TNC (A1), midbrain (B1) and hypothalamus (C1). (A2–C2) Images of the same brain regions from controls. Original magnification, 200×. (D) Plot of the counts of CGRP-positive cells in these three brain regions in the IS and control groups (*P < 0.05). Scale bars: 50 μm. CGRP: Calcitonin gene-related peptide; IS: inflammatory soup; TNC: trigeminal nucleus caudalis.