Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan;14(1):87–99. doi: 10.4103/1673-5374.243713

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Neural Regeneration Research

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

PMC Copyright notice

Lutein or DHA treatment increases mitochondrial function

(A) Lutein-mediated increased mitochondrial respiration and was reversed by PI3K inhibitor LY294002 co-treatment. (B) DHA-mediated increased mitochondrial respiration and was reversed by LY294002 co-treatment. (C) Quantification of mitochondrial respiration by subtracting non-mitochondrial OCR (after adding R/A) from OCR before adding oligomycin (F_(5,11) = 88.9, P < 0.01). (D) Quantification of mitochondrial maximum capacity by subtracting non-mitochondrial OCR (after adding R/A) from OCR after adding FCCP (F_(5,11) = 68, P < 0.01). (E) Quantification of ATP linked respiration by subtracting non-mitochondrial OCR (after adding R/A) from OCR after adding oligomycin (F_(5,11) = 32.5, P < 0.01). (F) Quantification of proton leak by subtracting non-mitochondrial OCR (after adding R/A) from OCR before adding FCCP (F_(5,11) = 55.5, P < 0.01). Statistical significance: *P < 0.05 and **P < 0.01, vs. CON (one-way analysis of variance followed by the least significant difference post hoc test), data are expressed as the mean ± SEM, three replications in each group. OCR: Oxygen consumption rate; FCCP: carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; Oligo: oligomycin (2 μM); R/A: rotenone and antiomycin (1 μM); CON: control; LUT: lutein (5 μM); LUTLY: lutein (5 μM) + LY294002 (10 μM); DHA: docosahexaenoic acid (10 μM); DHALY: DHA (10 μM) + LY294002 (10 μM); LY: LY294002 (10 μM).