Figure 4.

Bar plots of T2-FLAIR and diffusion metrics in the three types of ROIs.

The lesion, perilesion, and NAWM ROIs are color-coded in red, blue, and green, respectively. Error bars denote the standard deviation across 36 ROI sets. The overhead arrows denote significant differences in measurements between pairs of ROIs at a Bonferroni-corrected P threshold of 0.017 (Table 6). Note that T2-FLAIR intensity is not a quantitative measure; thus, it was not tested for statistical significance at the group level. FLAIR: Fluid attenuated inversion recovery; NAWM: normal-appearing white matter; ROIs: regions of interest.