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. Author manuscript; available in PMC: 2018 Nov 29.
Published in final edited form as: Nature. 2017 Dec 13;552(7685):410–414. doi: 10.1038/nature25146

Figure 5 |. Relationship between conversion of phophoinositides and known structural events during clathrin-mediated endocytosis.

Figure 5 |

Drawing shows successive molecular conversions during clathrin-coated pit assembly and coated-pit budding and uncoating, with phosphoinositide composition (coloured dots and labelled coloured bars) deduced from recruitment of Aux1 sensors. Separation of a vesicle from its parent membrane blocks exchange with the plasma membrane and allows stable lipid conversions.