Table 4.
Power of FAM19A4 methylation, cytology and HPV16/18 genotyping for detection HSIL alone and ≥ HSIL
| Triage | Endpoint | AUC (95%CI) | Sensitivity (%(95%CI)) | Specificity (%(95%CI)) | YI (%) |
|---|---|---|---|---|---|
| FAM19A4 | HSIL alone | 0.67(0.58–0.76) | 56.14(43.26–69.02) | 81.44 (73.71–89.18) | 37.58 |
| ≥HSIL | 0.81(0.75–0.87) | 75.42(67.66–83.19) | 81.44 (73.71–89.18) | 56.86 | |
| Cytology | HSIL alone | 0.69(0.61–0.78) | 78.95(68.36–89.53)a | 59.79(50.04–69.55) c | 38.74 |
| ≥HSIL | 0.71(0.64–0.79) | 83.05(76.28–89.82) ** | 59.79(50.04–69.55)d | 42.84 | |
| HPV16/18 genotyping | HSIL alone | 0.58(0.49–0.68) * | 49.12(36.14–62.10) ** | 67.0(57.65–76.37) c | 16.13 |
| ≥HSIL | 0.66(0.59–0.74) | 65.25(56.66–73.85) ** | 67.01(57.65–76.37)d | 32.26 | |
| FAM19A4 and HPV16/18 | HSIL alone | 0.67(0.58–0.76) | 73.68(62.25–85.12) a | 59.79(50.04–69.55) c | 33.48 |
| ≥HSIL | 0.73(0.66–0.80) | 86.44(80.26–92.62)b | 59.79(50.04–69.55) d | 46.23 |
AUC area under curve, YI youden index
*P>0.05
**compared with the sensitivity of FAM19A4 in group of HSIL alone or ≥ HSIL, P>0.05
a: compared with the sensitivity of FAM19A4 in group of HSIL alone, P < 0.05
b: compared with the sensitivity of FAM19A4 in group of ≥HSIL, P<0.05
c: compared with the specificity of FAM19A4 in group of HSIL alone,P<0.05
d: compared with the specificity of FAM19A4 in group of ≥HSIL,P<0.05