Fig. 3.

Median baseline bone biomarker levels according to best overall response after 48 weeks of treatment. Statistical significance was accepted when P < 0.05. P-values for difference in baseline biomarker values based on overall response were established using the Kruskal–Wallis test. Patients were classified with an unknown response status at 48 weeks due to early discontinuation of study treatment, missing Response Evaluation Criteria In Solid Tumors data at week 48, or loss to follow-up. Abbreviations: CTX, C-terminal cross-linking telopeptide of type 1 collagen; P1NP, procollagen type 1 N-terminal peptide; PTH, parathyroid hormone.