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. 2018 Nov 22;25(1):1811–1825. doi: 10.1080/10717544.2018.1494224

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Toxicity assessment of F/A-PLGA@DOX/SPIO. (a) Hematological analysis of normal and different treatments of nude mice after 28 days. Serum biochemistry indexes including blood glucose (GLU), low-density lipoprotein cholesterol (LDL-C), total protein (TP), aspartate aminotransferase (AST), blood urea nitrogen (BUN), uric acid (UA), creatine kinase (CK), creatinine (CREA), serum total cholesterol (CHOL), triglyceride (TG), and lactate dehydrogenase (LDH). Values expressed as means ± SD of triplicate. Bars with different characters (a, b, c, and d) are statistically different at the p < .05 level. (b) Histology analysis of the major organs collected from different treatments of A549 tumor-bearing mice after 28 days (original magnification: 20×).