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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neuropharmacology. 2017 Oct 25;128:301–313. doi: 10.1016/j.neuropharm.2017.10.026

Fig. 1. Functional cross-talk between group-I and group-II mGlu receptors in transfected HEK 293 cells.

Fig. 1.

Expression of mGlu1 and mGlu5 receptors in cells transfected with mGlu1 or mGlu5 cDNA in the absence or presence of mGlu2, mGlu3 receptors or GRK2-C-ter cDNA is shown in (A). Stimulation of PI hydrolysis by DHPG and/or LY379268 in cells expressing mGlu1 or mGlu5 receptors with or without mGlu2 or mGlu3 receptors is shown in (B). The effect of GRK2-C-ter on the synergism between mGlu3 and mGlu1 or mGlu5 receptors is shown in (C). In (B) and (C), values are mean ± S.E.M. of 3–9 determinations. p < 0.05 (Two-way ANOVA + Bonferroni test) * vs. the respective basal and # vs. the respective DHPG alone (B 1: F(1,16) = 4.69 for transfection factor and F(3,16) = 43.93 for treatment factor; B2: F(1,16) = 11.39 for transfection factor and F(3,16) = 112.73 for treatment factor; B3: F(1,25) = 2.17 for transfection factor and F(3,25) = 27.00 for treatment factor; B4: F(1,47) = 1.04 for transfection factor and F(3,47) = 41.17 for treatment factor; C1: F(1,25) = 4.89 for transfection factor and F(3,25) = 28.97 for treatment factor; C2: F(3,29) = 30.78 for treatment factor).