Skip to main content
. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neuropharmacology. 2017 Oct 25;128:301–313. doi: 10.1016/j.neuropharm.2017.10.026

Fig. 6. Saturating mGlu3 receptor-LTD requires the activation of mGlu5 receptors.

Fig. 6.

mGlu3 receptor-dependent-LTD requires activation of mGlu5 receptors. (A) Representative experiment displaying LTD of excitatory transmission following bath application of the mGlu2/3 receptor agonist LY379268 (100 nM) for 10 min. Inset, representative excitatory postsynaptic current (EPSC) before and after LTD. All scale bars denote 100 ms and 100 pA. (B) Summary of LTD experiments. LY379268 induces LTD (54 ± 7% baseline, n = 5). (C) Representative experiment following application of the selective mGlu5 receptor NAM, MTEP (10 μM). (D) MTEP blocked the induction of LTD (89 ± 10% baseline, n = 5). Values are mean ± S.E.M. in A-D.