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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Eur J Med Chem. 2018 Oct 15;161:192–204. doi: 10.1016/j.ejmech.2018.10.020

Fig. 6. The predicted associations of natural products on coronary artery disease (CAD).

Fig. 6.

(A) Circos plot representing the predicted associations connecting 46 natural products with CAD. The predicted q values with corresponding Z-score are exhibited as connected lines (edges). Natural products with significant q values (q<10−5) are highlighted in bold font. The circos plot was drawn using Circos (v0.69). (B) A discovered drug-target-disease network connecting three typical natural products (resveratrol, luteolin and myricetin) as well as their corresponding targets of CAD proteins and their protein-protein interaction neighbors. The thickness of blue line is proportional to the predicted Z-score.