. Author manuscript; available in PMC: 2020 Jan 1.

Published in final edited form as: Eur J Med Chem. 2018 Oct 15;161:192–204. doi: 10.1016/j.ejmech.2018.10.020

Table 1.

The statistics comparison of four drug-target (compound-protein) networks.

Data set	N_D	N_T	N_DTI	Sparsity (%)

DTnet	1,812	1,335	11,333	0.468
CADDTnet	634	58	931	2.535
NPnet	500	2,020	6,229	0.617
CADNPnet	170	71	395	3.273

N_D: the number of drugs in network, N_T: the number of targets in network, N_DTI: the number of drug-target interactions (DTIs) or compound-protein interactions, Sparsity: the ratio of N_DTI to the number of all possible DTIs. CADDTnet represents the specific network connecting approved drugs with coronary artery disease (CAD) proteins derived from DTnet, while CADNPnet denotes to the specific network connecting natural products with CAD proteins extracted from NPnet.