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Model of GnIH/RFRP-3 actions as described herein in birds and mammals. The GnIH/RFRP-3 system acts as a central locus at which internal and external factors relevant for reproduction converge. In turn, GnIH/RFRP-3 acts on the reproductive axis to regulate physiology and behavior via actions at the GnRH and kisspeptin systems, the anterior pituitary, and through alterations in neurosteroid synthesis.
