Figure 2.

Pre-clinical data showing the effects of bisphosphonates on mechanical properties, partitioned out into effects on the mineral and collagen using small-angle x-ray scattering/wide-angle x-ray diffraction (SAXS/WAXS). Cortical bone beams from canine treated with alendronate (BP-treated) or vehicle (control) were assessed using uniaxial tensile testing. (A) Stress/Strain curves showing the strains measured in the bone tissue and compared with strains measured in (B) the mineralized collagen fibril (stagger in the gap zone) using SAXS and (C) the HA mineral crystalline lattice using WAXD experiments. Reproduced with permission from Bone. [13].