Table 1.
Effects of the dichloromethane extract, active fraction and thiophene derivatives on the growth of promastigote (PRO) and axenic amastigote forms (AMA) of L. amazonensis and cytotoxicity to J774G8 Macrophage Cells.
| IC50 (µg/mL) | CC50 (µg/mL) | SI | |||
|---|---|---|---|---|---|
| PRO | AMA | Macrophages | PRO | AMA | |
| Dichloromethane extract | 60.3 ± 9.2 | 77.7 ± 7.7 | 500 ± 50 | 8.3 | 6.5 |
| Active fraction | 57.5 ± 4.5 | 72.5 ± 7.5 | 440 ± 56.6 | 7.6 | 7.8 |
| Compound A | 7.7 ± 1.7 | 19.0 ± 4.7 | 370 ± 50 | 48.2 | 19.1 |
| Compound B | 21.3 ± 4.4 | 28.7 ± 2.6 | 335 ± 15 | 15.7 | 11.7 |
| Amphotericin B | 0.06 ± 0.0 | 0.23 ± 0.0 | ND | ND | ND |