Table 2.

Synergism between flavonoids and anticancer drugs.

Flavonoids	Mean GI50 (μM) [74]	Synergy with anti-cancer agents
Eupatin	4	mitoxantrone [75]
Silybin		Paclitaxel [76], TRAIL [77], SN-38 [78], mitoxantrone [78], cisplatin [79], carboplatin [79]
Quercetin	60	TRAIL [80], cisplatin [81], doxorubicin [82], vinblastine [83], paclitaxel [83], gemcitabine [84], topotecan [84]
Apigenin	27a	TRAIL [85,86], tamoxifen [87], fulvestrant [87]
Luteolin	N/A	Rapamycin [88], doxorubicin [89], cisplatin [90], TRAIL [91]
Kaempferol	N/A	TRAIL [92,93], vinblastine [83], paclitaxel [83], mitoxantrone [78]

^a The value was taken from the NCI website, http://dtp.nci.nih.gov/docs/dtp_search.html.