Table 11.
Influence of the ancillary ring substitution on antiviral activity.
| Compd. | Antiviral Activity on CEM cells IC50 (μM) | Cytotoxicity IC50 (μM) | Reference |
|---|---|---|---|
| 77e | 95.0 | 100.0 | 26 |
| 77f | 50.0 | 100.0 | 26 |
| 77g | NR | 43.0 | 26 |
| 77h | NR | 47.0 | 26 |
| 77i | 110.0 | >100.0 | 25 |
| 77j | 57.0 | 63.0 | 30 |
| 35 | 1.3 | >100.0 | 14 |
| 77l | >100.0 | >100.0 | 26 |
| 77m | 80.0 | >100.0 | 14 |
| 77n | 30.0 | 110.0 | 19 |
| 77o | 30.0 | 50.0 | 23 |
| 77p | 10.0 | 50.0 | 23 |
| 77q | 3.0 | 95.0 | 26 |
| 77r | 54.0 | 95.0 | 26 |
| 77s | 62.0 | >100.0 | 14 |
| 77t | 1.2 | 10.0 | 14 |
| 77u | 1.5 | 250.0 | 26 |
| 77w | 9.0 | 100.0 | 26 |
| 77x | 36.0 | 22.0 | 37 |
| 77y | 50.0 | >100.0 | 26 |
| 77aa | 6.0a | >100.0 | 19 |
| 77ab | 14.5a | >100.0 | 19 |
| 77ac | 26.0a | 230.0 | 19 |
NR: not reached, a Hela P4 cells.