Table 1.
Yields and major conditions for reactions shown in Scheme 1
| Entry | Heat | Cond. a | 2 (%) |
|---|---|---|---|
| 1 | ∆ | A | 2a (20%) |
| 2 | MW b | A | 2a (31%) |
| 3 | ∆ | B | 2a (57%) |
| 4 | MW b | B | 2a (50%) |
| 5 | ∆ | C | 2a (65%) |
| 6 | ∆ | D | 2e (47%) |
| 7 | ∆ | D | 2e (46%) |
a Conditions: A – Pd(OAc)2 (10 mol%), Ag2CO3 (1.5 equiv.), acetone, reflux, 18 h; B - Pd(OAc)2 (10 mol%), Ag2CO3 (1.5 equiv.), pinacolone, reflux, 18 h; C - Pd(OAc)2 (10 mol%), Ag2CO3 (1.1 equiv.), PEG-400, 140 °C, 10 min.; D - Pd(OAc)2 (10 mol%), Ag2CO3 (1.1 equiv.), PEG-400, 90 °C, 10 min
b MW: 40 W, 60 °C (acetone) or 110 °C (pinacolone), 40 min