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Yields and conditions for 2b-d
| Entry | Cond. a | 3 | 2 (%) |
|---|---|---|---|
| 1 | B b | 3b R1 = R2 = H | 2b (30%) |
| 2 | C | 3b R1 = R2 = H | 2d (26%) |
| 3 | B | 3c R1 = Cl; R2 = H | 2c (25%) |
| 4 | C | 3c R1 = Cl; R2 = H | 2c (72%) |
| 5 | C | 3d R1 = R2 = -OCH2O- | 2d (40%) |
a Conditions: B - Pd(OAc)2 (10 mol%), Ag2CO3 (1.5 equiv.), pinacolone, reflux, 18 h; C - Pd(OAc)2 (10 mol%), Ag2CO3 (1.1 equiv.), PEG-400, 140 °C, 10 min
b MW: 40 W, 60 °C,110 °C, 40 min
