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. Author manuscript; available in PMC: 2020 Jan 5.
Published in final edited form as: Mol Cell Endocrinol. 2018 Aug 29;479:27–38. doi: 10.1016/j.mce.2018.08.011

Figure 5.

Figure 5.

Neonatal GH effects on adult hepatic expression of female specific CYP2C12 (top) and female-predominant CYP2C7 (bottom). Hepatic CYP isoform levels (mRNA and protein) were determined in adult female rats neonatally treated solely or with a combination of vehicles (e.g. CONTROL), MSG, GH or GRF (upper case labels on x-axis). Half of the animals in groups neonatally exposed to MSG (i.e., MSG, MSG + GH and MSG + GRF) were implanted with rat GH releasing osmotic mini pumps to restore the continuous feminine GH profile (Fig. 4). All other animals received GH-vehicle releasing osmotic mini pumps (lower case labels on x-axis). Results are presented as a percentage of mRNA or protein in CONTROL rats arbitrarily designated as 100%. Values are means ± SD of at least 6 rats / data point. *P < 0.05, **P < 0.01 vs. CONTROL; † P < 0.05, ††P < 0.01 compares adult vehicle treatment of neonatal MSG + GH and MSG + GRF with vehicle treated MSG alone; ##P < 0.01 compares adult GH treatment with vehicle treatment of rats exposed to the same neonatal treatment. See Materials and Methods for all treatment details.