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. Author manuscript; available in PMC: 2020 Jan 5.
Published in final edited form as: Mol Cell Endocrinol. 2018 Aug 29;479:27–38. doi: 10.1016/j.mce.2018.08.011

Figure 7.

Figure 7.

Neonatal GH effects on adult hepatic expression of male-specific CYP2C11 (top) and sex-independent albumin (bottom). Hepatic mRNA levels of CYP2C11 and protein levels of albumin were determined in adult female rats neonatally treated with various regimens of vehicles (e.g. CONTROL), MSG, GH or GRF (upper case labels on x-axis). Half of the animals in groups neonatally exposed to MSG were implanted with rat GH releasing osmotic mini pumps to restore the continuous feminine GH profile (Fig. 4). All other animals received GH-vehicle releasing mini pumps (lower case labels on x-axis). Results are presented as a percentage of mRNA or protein in CONTROL rats artbitrarily designated as 100%. Values are means ± SD of at least 6 rats / data point. *P < 0.01 vs. CONTROL; #P < 0.01 compares adult GH treatment with vehicle treatment of rats exposed to the same neonatal treatment. See Materials and Methods for all treatment details. (CYP2C11 mRNA was not determined in GRF-alone and MSG + GRF treated rats.)