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The proposed MCPyV infectious cycle. MCPyV infects human dermal fibroblasts, and not other skin cell types, in ex vivo culture. MCPyV infectious particles (yellow circles) may reach the dermal layer through deep abrasions. Fibroblasts closest to the basement membrane and hair follicles support the greatest MCPyV infection in ex vivo culture. Cells within the hair follicle may support MCPyV infection or may be a critical route of transmission. (Not drawn to scale).
