Table 1.
Patient demographics and plasma/urine biomarker concentrations at baseline.
| DOXY Group (n=218) | Placebo Group (n=213) | Total (n=431) | |
|---|---|---|---|
| Demographics: | |||
| Age (years) | 54.60 (5.47) | 54.81 (5.81) | 54.70 (5.64) |
| Height (cm) | 162.84 (6.17) | 162.31 (6.05) | 162.59 (6.12) |
| Weight (kg) | 97.63 (18.08) | 96.06 (16.73) | 96.86 (17.42) |
| BMI (kg/m2) | 36.77 (6.29) | 36.46 (5.97) | 36.62 (6.13) |
| Outcomes: | |||
| JSW (mm) | 3.84 (1.30) | 3.77 (1.27) | 3.81 (1.28) |
| uCTX-II (ng/mmol) | 0.0171 (0.0277) | 0.0135 (0.0194) | 0.0153 (0.0240) |
| Biomarkers: | |||
| sTLR4 (ng/mL) | 3.43 (12.10) | 5.74 (30.35) | 4.59 (23.17) |
| LBP (μg/mL) | 17.07 (7.09) | 17.59 (6.22) | 17.32 (6.68) |
| IL-6 (ng/mL) | 1.44 (1.22) | 1.56 (3.24) | 1.50 (2.45) |
Values are mean (SD); BMI=body mass index; JSW=joint space width; uCTX-II=urinary collagen type II neoepitope normalized to urine creatinine; sTLR4=soluble Toll-like receptor 4; LBP=lipopolysaccharide binding protein; IL-6=interleukin-6