Table 2.

Association of inflammatory biomarkers with knee osteoarthritis structural progression (adjusted for treatment group and baseline outcome variable).

Outcome Variable	Biomarker†	n	Parameter Estimate (SE) or Odds Ratio* (95% CI)	p Value
	Z-LBP baseline	341	−9.63×10−2 (4.06×10−2)	0.018
	Z-TIC (LBP)12	253	−1.42×10−1 (4.90×10−2)	0.004
	Z-TIC (LBP)18	282	−1.20×10−1 (4.59×10−2)	0.009
ΔJSW16¶	Z-sTLR4 baseline	345	4.67×10−2 (5.03×10−2)	0.354
	Z-TIC (sTLR4)18	288	6.08×10−2 (4.64×10−2)	0.191
	Z-IL-6 baseline	343	−4.66×10−2 (3.95×10−2)	0.239
	Z-TIC (IL-6)18	285	−4.88×10−2 (4.63×10−2)	0.292
	Z-LBP baseline	341	1.357 (1.068, 1.724)	0.013
	Z-TIC (LBP)12	253	1.452 (1.097, 1.921)	0.009
	Z-TIC (LBP)18	282	1.497 (1.133, 1.977)	0.005
JSN16§	Z-sTLR4 baseline	345	0.751 (0.392, 1.439)	0.388
	Z-TIC (sTLR4)18	288	0.502 (0.161, 1.564)	0.235
	Z-IL-6 baseline	343	1.493 (0.878, 2.55)	0.142
	Z-TIC (IL-6)18	285	1.362 (0.884, 2.10)	0.161
	Z-LBP baseline	235	−2.87×10−4 (5.93×10−4)	0.6290
	Z-TIC (LBP)12	206	−1.34×10−4 (6.49×10−4)	0.836
	Z-TIC (LBP)18	233	−7.55×10−4 (5.81×10−4)	0.897
Log10(ΔuCTX-Il18)¶	Z-sTLR4 baseline	234	1.96×10−3 (6.19×10−4)	0.002
	Z-TIC (sTLR4)18	233	1.68×10−3 (5.42×10−4)	0.002
	Z-IL-6 baseline	233	1.61×10−3 (1.26×10−3)	0.203
	Z-TIC (IL-6)18	230	2.09×10−3 (1.18×10−3)	0.079

^¶Models were adjusted for treatment group and corresponding baseline radiographic measures (JSW baseline for ΔJSW₁₆; uCTX-II at baseline for ΔuCTX-II18);

^§Models were adjusted for treatment group;

^†Data were Z score transformed;

^*Parameter estimates (beta coefficient estimates and standard error) from linear regression for continuous outcomes. Odds ratios only given for logistic regression models. ΔJSW₁₆=JSW at 16 months– JSW at baseline; JSN₁₆ dichotomized1 vs 0 based on joint space narrowing >0.5mm vs <0.05mm over 16 months; ΔCTX-II18=urinary CTX-II at 18 months – uCTX-II at baseline; TIC=time integrated over 12 or 18 months as indicated by subscript; remainder of abbreviations as in Table 1; p<0.05 in bold