Table 3.

Association of inflammatory biomarkers (LBP and sTLR4) with knee osteoarthritis progression (adjusted for treatment group, BMI and baseline outcome variable^*).

Outcome Variable	Biomarker†	n	Parameter Estimate (SE) or Odds Ratio*** (95% CI)	p Value
	Z-LBP baseline	341	−7.08×10−2 (4.18×10−2)	0.090
ΔJSW16	Z-TIC (LBP)12	253	−1.11×10−1 (5.21×10−2)	0.035
	Z-TIC (LBP)18	282	−7.90×10−2 (4.79×10−2)	0.100
	Z-LBP baseline	341	1.319 (1.029, 1.692)	0.029
JSN16	Z-TIC (LBP)12	253	1.406 (1.042, 1.898)	0.026
	Z-TIC (LBP)18	282	1.418 (1.06, 1.897)	0.019
Log10 (ΔuCTX-Il18)**	Z-sTLR4 baseline Z-TIC (sTLR4)18	234 233	1.98×10−3 (6.25×10−4) 1.71×10−3 (5.48×10−4)	0.0017 0.0021

^†Biomarker Data were Z score transformed.

^*Covariates include treatment group, age, BMI, and corresponding baseline radiographic measures (JSW baseline for ΔJSW₁₆; uCTX-II at baseline for ΔuCTX-II₁₈)

^**log ((Δ uCTX-II₁₈) was based on log₁₀₍(Δ uCTX-II₁₈+1-min((Δ uCTX-II₁₈ for the cohort)).

^***Odds ratios only given for logistic regression models. Others are beta coefficient parameter estimates and standard error (SE) from linear regression for continuous outcomes. p<0.05 in bold