Table 3.
Multivariate regression model with traditional risk factors and statin use.
| Protein | CEC | NCB | CB | Gender (F) | Age | BMI | HDL-C | Statin (Y) |
|---|---|---|---|---|---|---|---|---|
| APOA4 | ↑ | ↓ | ↑ | −0.012 | 0.072 | −0.152 | 0.097 | 0.173 |
| GELS | ↑ | ↓ | ↓ | 0.015 | −0.024 | −0.150 | 0.277 | −0.053 |
| ANT3 | ↑ | ↓ | −0.060 | 0.192 | −0.354 | −0.052 | 0.062 | |
| APOA1 | ↑ | ↓ | 0.116 | −0.015 | −0.243 | 0.435 | 0.186 | |
| APOA2 | ↑ | ↓ | 0.024 | −0.119 | −0.275 | 0.120 | 0.187 | |
| APOC1 | ↑ | ↓ | 0.036 | −0.098 | −0.300 | 0.305 | 0.000 | |
| CO2 | ↓ | ↑ | −0.050 | −0.047 | 0.292 | 0.120 | 0.055 | |
| PON1 | ↑ | ↓ | −0.149 | −0.272 | −0.074 | 0.254 | 0.006 | |
| A2AP | ↑ | −0.044 | 0.013 | −0.101 | 0.051 | −0.045 | ||
| APOC3 | ↑ | 0.109 | −0.077 | −0.041 | 0.240 | 0.186 | ||
| RET4 | ↑ | −0.305 | −0.143 | −0.298 | 0.129 | 0.077 | ||
| CERU | ↓ | −0.020 | −0.205 | −0.060 | 0.075 | −0.077 | ||
| CO4A | ↓ | −0.182 | −0.150 | 0.164 | 0.165 | −0.026 | ||
| CO9 | ↓ | 0.132 | 0.105 | 0.250 | −0.051 | −0.075 | ||
| IGHG1 | ↓ | −0.039 | −0.060 | −0.250 | −0.215 | −0.063 | ||
| KLKB1 | ↓ | 0.023 | −0.238 | 0.001 | 0.030 | 0.000 | ||
| ANGT | ↓ | 0.023 | −0.012 | −0.211 | 0.034 | 0.058 | ||
| APOF | ↓ | −0.140 | −0.029 | −0.286 | 0.266 | 0.118 | ||
| KAIN | ↓ | 0.002 | −0.059 | −0.362 | −0.073 | 0.172 | ||
| C1S | ↑ | −0.172 | 0.010 | 0.089 | 0.031 | −0.088 | ||
| CFAB | ↑ | 0.244 | −0.030 | 0.290 | −0.117 | −0.066 | ||
| CO3 | ↑ | 0.140 | 0.066 | 0.292 | −0.268 | 0.138 | ||
| IGHA1 | ↑ | −0.158 | −0.089 | 0.109 | 0.012 | 0.063 | ||
| SAA | ↑ | 0.256 | 0.033 | 0.409 | −0.017 | −0.045 | ||
| A2MG | ↑ | 0.074 | 0.264 | −0.020 | 0.030 | 0.008 | ||
| APOC2 | ↑ | 0.115 | 0.062 | −0.081 | −0.080 | 0.166 | ||
| VTDB | ↑ | −0.046 | 0.100 | −0.219 | −0.016 | 0.094 | ||
| A1BG | ↓ | 0.274 | −0.011 | 0.051 | 0.001 | 0.101 | ||
| CAMP | ↓ | 0.044 | −0.274 | 0.043 | 0.248 | −0.168 | ||
| CFAH | ↓ | −0.019 | −0.178 | 0.121 | −0.088 | −0.141 | ||
| FINC | ↓ | 0.035 | −0.158 | 0.045 | 0.119 | 0.010 | ||
| HRG | ↓ | 0.029 | 0.024 | −0.068 | 0.029 | −0.192 | ||
| KNG1 | ↓ | 0.038 | −0.111 | −0.118 | 0.076 | 0.015 | ||
| PON3 | ↓ | −0.053 | −0.059 | 0.178 | −0.043 | −0.091 | ||
| Totals: | 4 | 6 | 15 | 9 | 5 |
Arrows indicate directionality of association between proteins and CEC or burden measures.
Upward arrows = positive association and downward = negative association.
Linear regression model for each protein includes all clinical variables.
•
Indicates association with CEC or burden measure with VIP score > 1.3
Numerical values are standardized beta coefficient. Shading indicates level of statistical significance. No fill (white) is not statistically significant.
p < 0.05 p < 0.01 p < 0.001 p < 0.0001