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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Exp Neurol. 2018 Oct 1;311:162–172. doi: 10.1016/j.expneurol.2018.09.016

Figure 2.

Figure 2.

Effect of IGF-1 on hBMECs cell adhesion and cytoskeletal organization: Compared to normoxic conditions (A and B), cultures exposed to OGD show retracted cells with low vinculin labeling (C) and bright stress fibers (green phalloidin, D). IGF-1-treated cells displayed flattened cell morphology, similar to normoxic conditions, with brighter vinculin staining both in the cytoplasm and at the cell perimeter (E), with fewer stress fibers compared to OGD (F), while this pattern was reversed in cells treated concurrently with IGF-1+JB-1 (G&H). Bar: 50 um.