Table 2.
Cohorts | MARKER | EA | NEA | OR | OR_95L | OR_95U | N (cases + controls) | p |
---|---|---|---|---|---|---|---|---|
GoDARTS (severe DR, type 2) | rs3913535 | C | T | 1.55 | 1.34 | 1.79 | 4666 (560 + 4,106) | 4.05 × 10−9 |
rs10765219 | T | G | 1.54 | 1.31 | 1.80 | 4666 | 7.41 × 10−8 | |
rs11018670 | G | A | 1.55 | 1.33 | 1.80 | 4666 | 1.23 × 10−8 | |
SDR (general DR, type 2) | rs3913535 | C | T | 0.98 | 0.95 | 1.01 | 2016 (1,151 + 865) | 0.25 |
rs10765219 | T | G | 1.04 | 1.004 | 1.07 | 2016 | 0.02 | |
rs11018670 | G | A | 1.03 | 1.004 | 1.07 | 2016 | 0.03 | |
AUST (general DR, type 2) | rs3913535 | C | T | 1.05 | 0.84 | 1.30 | 780 (346 + 434) | 0.68 |
rs10765219 | T | G | 1.04 | 0.84 | 1.28 | 780 | 0.73 | |
rs11018670 | G | A | 1.05 | 0.85 | 1.30 | 780 | 0.62 | |
BMES (general DR, type 2) | rs3913535 | C | T | 1.89 | 0.90 | 3.99 | 162 (15 + 147) | 0.09 |
rs10765219 | T | G | 2.76 | 1.31 | 5.79 | 162 | 0.007 | |
rs11018670 | G | A | 2.85 | 1.35 | 6.02 | 162 | 0.006 | |
CHS2 (general DR, type 2) | rs3913535 | C | T | 1.12 | 0.30 | 4.11 | 116 (5 + 111) | 0.87 |
rs10765219 | T | G | 1.67 | 0.47 | 5.92 | 116 | 0.43 | |
rs11018670 | G | A | 1.69 | 0.48 | 5.93 | 116 | 0.42 | |
FinnDiane (general DR, type 1) | rs3913535 | C | T | 1.05 | 0.92 | 1.21 | 2670 (1,638 + 1,032) | 0.53 |
rs10765219 | T | G | 1.13 | 0.99 | 1.29 | 2670 | 0.08 | |
rs11018670 | G | A | 1.09 | 0.95 | 1.23 | 2670 | 0.23 | |
GoKinD; EDIC (general DR type 1) | rs3913535 | C | T | 1.03 | 0.91 | 1.16 | 2829 (973 + 1,856) | 0.52 |
rs10765219 | T | G | 1.08 | 0.95 | 1.22 | 2829 | 0.21 | |
rs11018670 | G | A | 1.05 | 0.91 | 1.21 | 2829 | 0.42 | |
Meta‐analysis without GoDARTS | rs3913535 | C | T | 0.99 | 0.96 | 1.02 | 8573 (4,128 + 4,445) | 0.42 |
rs10765219 | T | G | 1.05 | 1.02 | 1.08 | 8573 | 0.003 | |
rs11018670 | G | A | 1.03 | 1.01 | 1.06 | 8573 | 0.007 | |
Meta‐analysis all Caucasian cohorts | rs3913535 | C | T | 1.01 | 0.98 | 1.03 | 13 239 (4688 + 8,551) | 0.71 |
rs10765219 | T | G | 1.07 | 1.03 | 1.10 | 13 239 | 9.02 × 10−5 | |
rs11018670 | G | A | 1.04 | 1.02 | 1.07 | 13 239 | 4.24 × 10−4 |
AUST = The Australian DR Genetics Case–Control Study, BMES = The Blue Mountain Eye Study, CHS2 = Cardiovascular Health Study 2, EA = effective allele, EDIC = The Epidemiology of Diabetes Interventions and Complications, FinnDiane = The Finnish Diabetic Nephropathy Study, GoDARTS = The Genetics of Diabetes Audit and Research Tayside, GoKinD = The Genetics of Kidneys in Diabetes study, N = number, NEA = non‐effective allele, OR = odds ratio, SDR = The Scania Diabetes Registry.