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. 2018 Sep 4;96(7):e811–e819. doi: 10.1111/aos.13769

Table 2.

The input information and the output meta‐analysis results of 7 Caucasian cohorts based on GWAMA (default setting)

Cohorts MARKER EA NEA OR OR_95L OR_95U N (cases + controls) p
GoDARTS (severe DR, type 2) rs3913535 C T 1.55 1.34 1.79 4666 (560 + 4,106) 4.05 × 10−9
rs10765219 T G 1.54 1.31 1.80 4666 7.41 × 10−8
rs11018670 G A 1.55 1.33 1.80 4666 1.23 × 10−8
SDR (general DR, type 2) rs3913535 C T 0.98 0.95 1.01 2016 (1,151 + 865) 0.25
rs10765219 T G 1.04 1.004 1.07 2016 0.02
rs11018670 G A 1.03 1.004 1.07 2016 0.03
AUST (general DR, type 2) rs3913535 C T 1.05 0.84 1.30 780 (346 + 434) 0.68
rs10765219 T G 1.04 0.84 1.28 780 0.73
rs11018670 G A 1.05 0.85 1.30 780 0.62
BMES (general DR, type 2) rs3913535 C T 1.89 0.90 3.99 162 (15 + 147) 0.09
rs10765219 T G 2.76 1.31 5.79 162 0.007
rs11018670 G A 2.85 1.35 6.02 162 0.006
CHS2 (general DR, type 2) rs3913535 C T 1.12 0.30 4.11 116 (5 + 111) 0.87
rs10765219 T G 1.67 0.47 5.92 116 0.43
rs11018670 G A 1.69 0.48 5.93 116 0.42
FinnDiane (general DR, type 1) rs3913535 C T 1.05 0.92 1.21 2670 (1,638 + 1,032) 0.53
rs10765219 T G 1.13 0.99 1.29 2670 0.08
rs11018670 G A 1.09 0.95 1.23 2670 0.23
GoKinD; EDIC (general DR type 1) rs3913535 C T 1.03 0.91 1.16 2829 (973 + 1,856) 0.52
rs10765219 T G 1.08 0.95 1.22 2829 0.21
rs11018670 G A 1.05 0.91 1.21 2829 0.42
Meta‐analysis without GoDARTS rs3913535 C T 0.99 0.96 1.02 8573 (4,128 + 4,445) 0.42
rs10765219 T G 1.05 1.02 1.08 8573 0.003
rs11018670 G A 1.03 1.01 1.06 8573 0.007
Meta‐analysis all Caucasian cohorts rs3913535 C T 1.01 0.98 1.03 13 239 (4688 + 8,551) 0.71
rs10765219 T G 1.07 1.03 1.10 13 239 9.02 × 10−5
rs11018670 G A 1.04 1.02 1.07 13 239 4.24 × 10−4

AUST = The Australian DR Genetics Case–Control Study, BMES = The Blue Mountain Eye Study, CHS2 = Cardiovascular Health Study 2, EA = effective allele, EDIC = The Epidemiology of Diabetes Interventions and Complications, FinnDiane = The Finnish Diabetic Nephropathy Study, GoDARTS = The Genetics of Diabetes Audit and Research Tayside, GoKinD = The Genetics of Kidneys in Diabetes study, = number, NEA = non‐effective allele, OR = odds ratio, SDR = The Scania Diabetes Registry.