TABLE 2.
Characteristics of Patients Who Were of Healthy Weight or Underweight at Diagnosis and Became Overweight/Obese During or After Therapy
| Variables | Total (n=277) | Overweight/Obese | Univariate Analysis | Multivariable Analysisa | |
|---|---|---|---|---|---|
| No (n=115) | Yes (n=162) | P-Value | P-Value | ||
| Age at diagnosis; N (%) | |||||
| 2 to <10 years | 211 | 72 (34.1) | 139 (65.9) | <0.001 | 0.001 |
| ≥10 years | 66 | 43 (65.2) | 23 (34.8) | ||
| Sex; N (%) | |||||
| Female | 122 | 48 (39.3) | 74 (60.7) | 0.515 | |
| Male | 155 | 67 (43.2) | 88 (56.8) | ||
| Ancestry; N (%) | |||||
| White | 193 | 80 (41.5) | 113 (58.5) | 0.216 | |
| Black | 43 | 21 (48.8) | 22 (51.2) | ||
| Native American | 19 | 4 (21.1) | 15 (78.9) | ||
| Other | 17 | 6 (35.3) | 11 (64.7) | ||
| No datab | 5 | 4 (80.0) | 1 (20.0) | ||
| Lineage; N (%) | |||||
| B cell | 237 | 92 (38.8) | 145 (61.2) | 0.027 | 0.548 |
| T cell | 40 | 23 (57.5) | 17 (42.5) | ||
| WBC at diagnosis; N (%) | |||||
| <50 × 109/L | 212 | 84 (39.6) | 128 (60.4) | 0.248 | |
| ≥50 × 109/L | 65 | 31 (47.7) | 34 (52.3) | ||
| CNS status; N (%) | |||||
| CNS-1 | 216 | 90 (41.7) | 126 (58.3) | 0.924 | |
| Other | 61 | 25 (41.0) | 36 (59.0) | ||
| Risk; N (%) | |||||
| Low | 144 | 44 (30.6) | 100 (69.4) | <0.001 | 0.092 |
| Standard/high | 133 | 71 (53.4) | 62 (46.6) | ||
a
Multivariable analysis was performed to determine the independent effect of each factor that had a P-value of less than 0.10 in univariate analysis.
b
Germline samples for ancestry analysis were not available.