Table 2.

Recovery of amyloid-β 1–42, Tau, and pTau181 from 0.1-ml and 0.5-ml aliquots

	Aβ1–42		Tau		pTau181
	YNC	AD	YNC	AD	YNC	AD
No. of subjects	20	81	20	81	20	81
Mean concentration 0.1 ml (pg/ml)	344	204	55.1	174	30.5	78.2
Mean concentration 0.5 ml (pg/ml)	499	299	58.0	164	29.2	76.8
p Value (mean concentration 0.1 ml vs. 0.5 ml)	< 0.0001	< 0.0001	ns	< 0.0001	ns	0.021
Mean change from 0.1 ml to 0.5 ml (%)	50.5	52.4	7.59	− 4.77	− 2.42	− 1.74

Abbreviations: Aβ Amyloid-β, AD Alzheimer’s disease, ns Not significant, YNC Young normal control subject

p Values calculated by paired t test