Fig. 6.

Effect of PPAR agonists on the cell invasion and migration phenotype of ALDH7A1-depleted cells. a-c Quantification of wound healing assays after 24 h migration. a Primary BJ cells, HUH7 and c CAKI2 cancer cells were treated with PPARα agonist or DMSO as a control. The migrated distance was measured (μm), and averages from three independently transduced cell lines were calculated (± SEM). d Quantification of cell invasion of primary BJ cells through Matrigel over 24 h. The bar plots show the percent of cells that crossed the gel barrier (average of 3 independent experiments ± SEM). The two-tailed Mann Whitney test was used to calculate p-values