Table 1.

Lipophilicity (Clog P) and Mtb wt gyrase inhibitory activity of the synthesized Schiff bases of isatins.

Compd. No.	Clog P a	Mtb wt gyrase IC50 (μM) b
3	0.72	>200
4	1.4	>200
5	0.87	>200
6	1.22	>200
7	1.75	>200
8	0.47	157.3
9	2.64	>200
10	3.37	>200
11	4.08	>200
12	3.51	>200
13	3.87	>200
14	0.72	>200
15	1.54	>200
16	1.14	>200
17	3.49	>200 (294)
18	3.28	~50, 56.3
19	2.52	89.9
20	4.7	>200
21	2.67	>200
22	5.36	>200
23	7.29	>200
24	6.53	>200
25	6.14	>200
26	0.27	>200

^a Calculated using PC-software package (MacLogP 2.0, BioByte Corp., CA, USA);

^b IC₅₀ of the reference drug moxifloxacin is 12.76, 11.23, 12.7 μM.