Fig 7. Nucleoporins interacting with MX2 are located at the cytoplasmic face of the nuclear pore.

Schematic diagram indicating the structure and organization of the nuclear pore complex as described in Hoelz et al [22]. Nucleoporins interacting with MX2 (identified by Y-2-H screening) are shown in red. Nucleoporins required for MX2 activity (defined as those for which specific depletion elicited >50% reduction in MX2 dependent inhibition of HIV-1, in either HeLa or U87-MG cells) are shown in bold. Nucleoporins that interact with MX2 and are required for MX2 inhibition are shown in red and bold.