Table 1.
Gastroprotective effect of compounds 1–12 on the HCl-EtOH-induced gastric lesion model in mice. All compounds were assessed at a single oral dose of 5 mg/kg.
| Compound | Lesion index (mm) Mean ± SEM | Protection (%) | Protected stomachs a |
|---|---|---|---|
| Tween | 27.2 ± 9.3 | ||
| Δ8(9) junicedric acid (II) | 5.3 ± 2.4 * | 79 | 4/9 |
| 1 | 15.3 ± 5.0 | 44 | |
| Tween | 25.0 ± 6.9 | 1/14 | |
| 2 | 8.7 ± 3.9 | 65 | 4/9 |
| 5 | 20.4 ± 3.6 | 18 | 0/9 |
| 6 | 6.5 ± 2.7 * | 74 | 3/8 |
| 7 | 11.5 ± 4.4 | 54 | 1/8 |
| 8 | 3.9 ± 1.9 * | 84 | 5/9 |
| 11 | 23.5 ± 3.6 | 6 | 0/10 |
| 12 | 27.4 ± 6.8 | - | 0/7 |
| Tween | 43.3 ± 8.2 | 0/9 | |
| 3 | 17.9 ± 4.6 ** | 59 | 0/8 |
| 4 | 19.3 ± 5.0 ** | 55 | 0/9 |
| 9 | 15.7 ± 4.5 ** | 64 | 0/9 |
| 10 | 10.2 ± 3.5 ** | 76 | 3/9 |
| Lansoprazole (20 mg/kg) | 9.4 ± 1.2 ** | 73 | 6/9 |
* and **: P < 0.05 different from untreated control (Tween); a Number of stomachs which were completely protected from any visible bleeding. One-way ANOVA with Student-Newman-Keuls post-hoc test.