Table 1.
Compound | CC50 a (µM) | Influenza A (A/Udorn/307/72) | |
---|---|---|---|
IC50b (µM) | SI c | ||
Patchouli alcohol | >20.0 | 4.03 ± 0.23 * | >4.96 |
Oseltamivir | >20.0 | 0.031 ± 0.012 | >645.16 |
Values in this table represent the mean values (±SD) of three independent experiments (P < 0.01).
a Cytotoxic effect was determined by MTT assay. CC50 was the concentration that showed 50% cytotoxic effects in MDCK cells; b Antiviral activity was determined by MTT assay. IC50 was the concentration that inhibited 50% of Influenza A [(Leningrad/134/17/1957) (H2N2)] virus replication in MDCK; c The selective index (SI) was calculated as CC50/IC50. The symbol * indicate a very significant difference p < 0.01 with respect to positive control (oseltamivir).