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. 2010 Jun 1;15(6):3958–3992. doi: 10.3390/molecules15063958

Table 3.

Inhibition of HIV-1 IN and APE1 catalytic activities by rhodanines 22–26.

Compound Structure Inhibition of IN catalytic activity IC50 (µM) Inhibition of APE1 catalytic activityIC50 (μM)
3’-Processing Strand Transfer
22 graphic file with name molecules-15-03958-i017.jpg >100 90 >100
23 graphic file with name molecules-15-03958-i018.jpg >100 >100 83
24 graphic file with name molecules-15-03958-i019.jpg >100 >100 >100
25 graphic file with name molecules-15-03958-i020.jpg >100 >100 >100
26 graphic file with name molecules-15-03958-i021.jpg >100 >100 -