Table 4.

Inhibition of HIV-1 IN and APE1 catalytic activities by rhodanines 27–40.

Compound	Structure	Inhibition of IN catalytic activity IC50 (µM)		Inhibition of APE1 catalytic activityIC50 (μM)
		3’-Processing	Strand Transfer
27		83 ± 25	20	>100
28		44 ± 13	30 ± 19	>100
29		74 ± 18	72 ± 23	>100
30		47 ± 30	>100	>100
31		>100	>100	>100
32		82 ± 5	83 ± 3	>100
33		>100	>100	>100
34		33 ± 19	26 ± 14	>100
35		45 ± 24	61 ± 11	>100
36		46 ± 5	>100	>100
37		33 ± 7	35 ± 6	>100
38		51 ± 25	32 ± 11	65 ± 33
39		47 ± 20	31 ± 16	>100
40		>100	95	>100