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. 2011 Jun 14;16(6):4861–4883. doi: 10.3390/molecules16064861

Table 3.

Cytotoxicities of derivatives of luotonin A on ring E and isosteres.

graphic file with name molecules-16-04861-i003.jpg
R7 R8 R9 R10 IC50 (μM)
Galactose [25] ADR-Res [40] HeLa [40] MCF7 [40] H460 [41] a)
1aa H H H H 0.58 5 3 3 7.7
1n H H F H 9.58 - - - -
1o H NH2 H H 15.7 - - - -
1p H H H Cl - - - - 13
1q H H NO2 H - - - - 23
1r CH3 H H H - - - - 7
1s H H Cl H - - - - 45
1t H H OH H - - - - 3.8
1u Cl H H H - 13 >10 10 -
1v NH2 H H H - 3 2 2 -
1w OCH3e H H H - >20 12 >20 11
1x H OH OH H - >20 6 10 -
46 11.8 - - - -
47 91.4 - - - -
CPT 0.86 0.01 0.01 0.01 -
SN-38 - - - - 0.21 b)

a) Values obtained from 72 h culture. b) Values from 1 h culture.