Table 3.
R7 | R8 | R9 | R10 | IC50 (μM) | |||||
---|---|---|---|---|---|---|---|---|---|
Galactose [25] | ADR-Res [40] | HeLa [40] | MCF7 [40] | H460 [41] a) | |||||
1aa | H | H | H | H | 0.58 | 5 | 3 | 3 | 7.7 |
1n | H | H | F | H | 9.58 | - | - | - | - |
1o | H | NH2 | H | H | 15.7 | - | - | - | - |
1p | H | H | H | Cl | - | - | - | - | 13 |
1q | H | H | NO2 | H | - | - | - | - | 23 |
1r | CH3 | H | H | H | - | - | - | - | 7 |
1s | H | H | Cl | H | - | - | - | - | 45 |
1t | H | H | OH | H | - | - | - | - | 3.8 |
1u | Cl | H | H | H | - | 13 | >10 | 10 | - |
1v | NH2 | H | H | H | - | 3 | 2 | 2 | - |
1w | OCH3e | H | H | H | - | >20 | 12 | >20 | 11 |
1x | H | OH | OH | H | - | >20 | 6 | 10 | - |
46 | 11.8 | - | - | - | - | ||||
47 | 91.4 | - | - | - | - | ||||
CPT | 0.86 | 0.01 | 0.01 | 0.01 | - | ||||
SN-38 | - | - | - | - | 0.21 b) |
a) Values obtained from 72 h culture. b) Values from 1 h culture.